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Joe Fresh - New York

One of the most talked-about store openings of the year, this Canadian fast fashion store is finally painting the Big Apple orange. Creative director Joe Mimran started the Joe Fresh's Stateside expansion with a small holiday pop-up shop on New York's Upper East Side last October, then followed it up with the company's first official US outpost on 110 Fifth Ave. The brand's received tons of editorial support—and to think it all began in a string of Canadian grocery stores.

110 Fifth Avenue, 212-366-0960, joefresh.com

Kelly Wearstler - Los Angeles

Best known for her gorgeous interiors projects and beautiful blog, shelter guru Kelly Wearstler opened a flagship boutique on Melrose Avenue in late November. The 2,800-square-foot space is filled with sculptures and skylights, brass fixtures and pyrite-embellished accents, all of which reflect the designer's signature organic-meets-feminine aesthetic. Items for sale include Wearstler's ready-to-wear collection, home goods and jewelry—plus her best-selling book Hue.

Jonathan Adler - Atlanta

"Happy Chic" designer (and Simon Doonan's better half) Jonathan Adler opened his first-ever Atlanta store this past year. His 14th freestanding location to date, the shop brings Adler's trademark groovy furnishings (modernist pottery and retro-minded lighting fixtures) to the Deep South.

1198 Howell Mill Road, 404-367-0414, jonathanadler.com

Alchemist - Miami

This Miami Beach fixture is a Lucky favorite for good reason—it's easily one of the most visually-appealing boutiques we've ever visited. High atop a Herzog & de Meuron-designed parking garage that hugs Lincoln Road, this store sells labels like Givenchy, Dries Van Noten and Balenciaga, all displayed in a stunning museum-style setting.

1111 Lincoln Road, 305-531-4815, shopalchemist.com

Fivestory - New York

This multi-level designer boutique, housed in an elegant Upper East Side townhouse, is set to open this March after a brief preview run—watch this space for an exact date. Luxe wares will range from structured Victoria Beckham dresses to delicate headpieces by Maison Michel, all displayed in a space decorated by interiors wunderkind Ryan Korban.

18 East 69 Street, 212-288-1338, fivestoryny.com

Vivienne Westwood - Los Angeles

Last April, the famously flame-haired UK designer headed across the pond to set up shop on our side of the Atlantic. The new 10,000-square-foot space on Melrose Avenue holds Dame Viv's Gold, Red, Anglomania and menswear labels as well as her famous tartan handbags and other accessories. We're thinking there are probably a few wedding-worthy ensembles tucked in amongst the racks, too.

8320 Melrose Avenue, 323-951-0711, viviennewestwood.co.uk

Sandro - New York

Sandro's new West Village space is a wellspring of Parisian chic. From striped silk shifts to cable knits tricked out with bowties, the French import has basically managed to fit everything we ever wanted to own into a single shop. And for days you're feeling more daring: leopard-spotted accents abound.

415 Bleecker Street, 646-438-9335, us.sandro-paris.com

Ikram - Chicago

With a beautiful mix of labels like Azzedine Alaïa, Proenza Schouler and Junya Watanabe, the Gold Coast's foremost high-end boutique caters to the well-dressed and powerful (Michelle Obama, anyone?). Founder Ikram Goldman recently moved the store to a much larger space that wows in terms of both its design and designers.

15 East Huron Street, 312-587-1000, ikram.com

BHLDN - Houston

Launched early last year by the team behind Urban Outfitters and Anthropologie, bridal brand BHLDN started out as an online-only venture. But after a successful six months of sales, the company set up shop—of the brick-and-mortar variety—in Houston. Elegantly furnished with antique pieces, the flagship houses gowns, tableware and other wedding-day essentials.

Highland Village Center, 4056 Westheimer Road, 713-599-1917, bhldn.com

Stella McCartney - New York

Stella's gone SoHo. After a decade spent in NYC's Meatpacking District, the Brit designer has packed up her flagship and relocated to greener (and more tourist-friendly) pastures. The two-level space has a sustainable-oak floor, cool brass columns and designated areas for Stella's childrenswear and long-running Adidas collab. Now finally open for business, the new store is celebrating by offering an exclusive dog leash and collar designed especially for the relocation.

112 Greene Street, NYC, 212-255-1556, stellamccartney.com